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24/7 Lecture: Researching the mechanisms of actions of 5-fluorouracil in wild-type and ThyA Escherichia coli

Posted on Tuesday, June 4, 2024 by for 24/7 Lecture.

This 24/7 Lecture is also available on Instagram.

24 seconds: 5-Fluorouracil (5-FU) is a chemotherapy drug used to treat various cancers by inhibiting thymidylate synthetase (TS), essential for DNA synthesis. Our research focused on its mechanisms in wild-type and ThyA mutants of E. coli. We found that minimal thymidine is required for bacterial growth, and deoxyuridine inhibits ThyA mutants while enhancing 5-FU's effectiveness. Additionally, ThyA mutants needed less thymidine than CarAB.

7 words: Investigating properties of 5-FU on Escherichia coli.

Rikza, Devin, Joanne (Class of 2024)